Experimental autoimmune encephalomyelitis (EAE) induced by sensitization with myelin
oligodendrocyte glycoprotein (MOG) is a T cell-dependent autoimmune disease that reproduces
the inflammatory demyelinating pathology of multiple sclerosis. We report that an
encephalitogenic T cell response to MOG can be either induced or alternatively suppressed as a
consequence of immunological cross-reactivity, or “molecular mimicry” with the extracellular
IgV-like domain of the milk protein butyrophilin (BTN).
Click here to download the document: Butryphillin modulates T cell response to Myelin